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PrfA thermoregulator UTR : ウィキペディア英語版 | PrfA thermoregulator UTR
The PrfA thermoregulator UTR is an RNA thermometer found in the 5' UTR of the ''prfA'' gene. In ''Listeria monocytogenes'', virulence genes are maximally expressed at 37°C (human body temperature) but are almost silent at 30°C. The genes are controlled by PrfA, a transcriptional activator whose expression is thermoregulated. It has been shown that the untranslated mRNA (UTR) preceding prfA, forms a secondary structure, which masks the ribosome binding region.〔 It is thought that at 37°C, the hairpin structure 'melts' and the SD sequence is unmasked.〔 ==References==
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