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PrfA thermoregulator UTR
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PrfA thermoregulator UTR : ウィキペディア英語版
PrfA thermoregulator UTR

The PrfA thermoregulator UTR is an RNA thermometer found in the 5' UTR of the ''prfA'' gene. In ''Listeria monocytogenes'', virulence genes are maximally expressed at 37°C (human body temperature) but are almost silent at 30°C. The genes are controlled by PrfA, a transcriptional activator whose expression is thermoregulated. It has been shown that the untranslated mRNA (UTR) preceding prfA, forms a secondary structure, which masks the ribosome binding region.〔 It is thought that at 37°C, the hairpin structure 'melts' and the SD sequence is unmasked.〔
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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